Grow Younger, Live Longer

In a nutshell
- VO2 max (maximum oxygen uptake) is the maximum amount of oxygen your body can use during intense exercise. It’s a key indicator of cardiovascular fitness and a predictor of overall health and longevity.
- Higher VO2 Max levels are associated with a lower risk of chronic diseases, improved heart health, and increased longevity.
- Although VO2 Max naturally declines with age, regular physical activity can slow this rate of decline.
- You can increase your VO2 Max through regular aerobic exercise, high-intensity interval training (HIIT), aerobic endurance training, strength training, and a combination of those. Nutrition and sleep also play crucial roles in this process.
VO2 Max is a game-changer in our journey toward a healthier, longer life! You might wonder, “What is VO2 Max, and why should I care about it?” That’s a great question and the very reason we are here today.
VO2 Max, or maximal oxygen uptake, is the maximum amount of oxygen your body can use during intense exercise. Think of it as the highest level of your body’s engine power when you are pushing yourself to the max during a workout. But why is it important? It’s simple – VO2 Max is a vital sign of your cardiovascular fitness and endurance. The higher your VO2 Max, the more oxygen your body can utilize, indicating better cardiovascular health and, crucially, a higher potential for a longer life span.
In fact, research shows that improving your VO2 Max can lead to lower risks of cardiovascular diseases and a better quality of life, even as you age. 1 Shephard RJ, Balady GJ. Exercise as cardiovascular therapy. Circulation. 1999 Feb 23;99(7):963-72. doi: 10.1161/01.cir.99.7.963. PMID: 10027821. Source
In this comprehensive guide, we’ll unravel the science of VO2 Max, reveal its substantial role in promoting longevity, and provide you with effective ways to boost your own VO2 Max levels. Our aim is to simplify complex scientific ideas into understandable, practical insights that can help you shape a healthier, more energized life.
Unpacking the VO2 Max Concept
The concept of VO2 Max may sound a bit complex, but it is actually a straightforward measurement of your body’s ability to use oxygen during strenuous exercise. Scientifically speaking, VO2 Max stands for maximal oxygen consumption. It’s measured in milliliters of oxygen used in one minute per kilogram of body weight (ml/kg/min).
So, what does this really mean for you? Imagine your body as an engine, and oxygen is the fuel. The maximum amount of fuel (oxygen) your body can utilize during high-intensity exercise is your VO2 Max.2 Hawkins MN, Raven PB, Snell PG, Stray-Gundersen J, Levine BD. Maximal oxygen uptake as a parametric measure of cardiorespiratory capacity. Med Sci Sports Exerc. 2007 Jan;39(1):103-7. doi: 10.1249/01.mss.0000241641.75101.64. Erratum in: Med Sci Sports Exerc. 2007 Mar;39(3):574. PMID: 17218891. PubMed Source The higher your VO2 Max, the more fuel your body can use, and the better your endurance and overall physical fitness.
VO2 Max is a standard indicator of cardiovascular fitness. Why is this? To answer this question, we need to understand how our body uses oxygen during exercise. When you exercise, your muscles work harder, requiring more energy. This energy comes from a process called cellular respiration, which uses oxygen to break down glucose and produce energy. As you increase the intensity of your exercise, your muscles need more energy, hence more oxygen. Your cardiovascular system (heart and blood vessels) responds by pumping more oxygen-rich blood to your muscles. Therefore, a higher VO2 Max means a more efficient heart and cardiovascular system.
VO2 Max is like a grade for how well your heart and lungs work when you exercise. It tells you how much oxygen your body can use during intense workouts. The higher the number, the fitter you are.
But the key question remains, why should we care about VO2 Max in the first place? The answer is its significant implication on our health and longevity. Studies have linked a higher VO2 Max to a lower risk of chronic diseases and a longer, healthier life.3 Khan H, Kunutsor S, Rauramaa R, Savonen K, Kalogeropoulos AP, Georgiopoulou VV, Butler J, Laukkanen JA. Cardiorespiratory fitness and risk of heart failure: a population-based follow-up study. Eur J Heart Fail. 2014 Feb;16(2):180-8. doi: 10.1111/ejhf.37. Epub 2013 Dec 14. PMID: 24464981. PubMed Source 4 Strasser B, Burtscher M. Survival of the fittest: VO2max, a key predictor of longevity? Front Biosci (Landmark Ed). 2018 Mar 1;23(8):1505-1516. doi: 10.2741/4657. PMID: 29293447. PubMed Source In the next sections, we will delve deeper into how VO2 Max changes with aging and its compelling relationship with longevity. But for now, remember this: VO2 Max is a crucial measure of your physical fitness, and improving it can significantly enhance your health and lifespan.
The Impact of Age on VO2 Max
VO2 Max is generally higher in men than in women and higher in athletes than in non-athletes. It also doesn’t stay constant throughout your life. In fact, VO2 Max typically peaks in your late teens or early twenties and gradually declines with age. Although it is well established that VO2 Max tends to decline with age, the rate of this decline can vary substantially between individuals who maintain a regular exercise regimen and those who do not.
Research indicates that sedentary individuals can expect a decrease in VO2 Max of about 10% per decade after the age of 30.5 Fleg JL, Morrell CH, Bos AG, Brant LJ, Talbot LA, Wright JG, Lakatta EG. Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation. 2005 Aug 2;112(5):674-82. doi: 10.1161/CIRCULATIONAHA.105.545459. Epub 2005 Jul 25. PMID: 16043637. PubMed Source This decline can be attributed to a number of physiological changes associated with aging, including decreased heart function, lower lung capacity, and reduced muscle mass.
However, this rate of decline is not inevitable. Individuals who engage in regular aerobic exercise can slow the rate at which their VO2 Max decreases. Some studies have shown that individuals who maintain a consistent exercise regimen can reduce the rate of decline to as little as 5% per decade, effectively halving the loss experienced by their sedentary peers.6 Hawkins SA, Wiswell RA, Marcell TJ. Exercise and the master athlete–a model of successful aging? J Gerontol A Biol Sci Med Sci. 2003 Nov;58(11):1009-11. doi: 10.1093/gerona/58.11.m1009. PMID: 14630882. PubMed Source
Individuals can expect a decrease in VO2 Max of about 10% per decade after the age of 30. Individuals who maintain a high level of aerobic exercise can slow that rate of decline to about 5% per decade.
This highlights the significant impact of lifestyle on our cardiovascular health as we age. By committing to regular exercise, we can actively combat the natural decline in VO2 Max and potentially extend our healthspan and lifespan.
That being said, it’s never too late to start. Even individuals who regularly exercise later in life can significantly improve their VO2 Max and overall cardiovascular health. In the realm of health and longevity, every step counts, regardless of when you start. Remember, it’s always advisable to consult a healthcare or fitness professional before starting any new fitness regimen.
How Does VO2 Max Affect Longevity?
The relationship between VO2 Max and longevity is a remarkable area of scientific research. Simply put, a higher VO2 Max equates to a greater capacity for exercise and better cardiovascular health, which are closely linked to a longer, healthier life.
A landmark study in 2009 meticulously examined the link between cardiorespiratory fitness, as measured by VO2 Max, and all-cause mortality and cardiovascular events.7 Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA. 2009 May 20;301(19):2024-35. doi: 10.1001/jama.2009.681. PMID: 19454641. PubMed Source They found that higher levels of cardiorespiratory fitness were associated with a reduced risk of all-cause mortality and heart-related events. In other words, individuals with a higher VO2 Max are generally expected to live longer, healthier lives than those with a lower VO2 Max.
Why is this the case? To understand, we must consider the role of the cardiovascular system in our overall health. The heart, blood vessels, and blood are the key components of this system, supplying oxygen and nutrients to every part of our body, from our brain to our muscles. When our cardiovascular fitness is high, our heart is stronger, and our blood vessels are more efficient at delivering oxygen. This, in turn, allows our body to function more effectively and resiliently, potentially fending off a variety of diseases such as heart disease, diabetes, and obesity.
Furthermore, a higher VO2 Max often indicates a more active lifestyle, which carries additional benefits beyond improved cardiovascular health. Regular physical activity is associated with improved mental health, lower risk of certain cancers, better sleep, and improved bone health, among others.
In summary, a high VO2 Max, reflecting superior cardiorespiratory fitness, can serve as a robust shield against various health issues, potentially extending our lifespan. The evidence is compelling: enhancing your VO2 Max could be your passport to not just a longer life, but a life filled with more vitality and health. In the next section, let’s discuss the practical ways you can measure and improve your VO2 Max.
Measuring Your VO2 Max
Understanding how to measure VO2 Max can be valuable for monitoring your progress as you implement strategies to improve it. There are both professional and simple at-home methods to measure VO2 Max.
In a professional setting, VO2 Max is typically measured using a maximal exercise test performed on a treadmill or bicycle ergometer, under the supervision of a fitness or health professional. This process involves wearing a mask connected to a machine that accurately measures the volume and oxygen content of inhaled and exhaled air. As you work out more intensively, your body’s oxygen consumption is recorded until it reaches a plateau, despite increasing exercise intensity—this plateau is your VO2 Max. While this test is the most accurate method, it requires specialized equipment and professional supervision.
At home, you can estimate your VO2 Max using several simpler methods.
Cooper Test
One of the most common is the Cooper test. It is a straightforward method developed by Dr. Kenneth Cooper in 1968 for the military to assess fitness.8 McNaughton L, Hall P, Cooley D. Validation of several methods of estimating maximal oxygen uptake in young men. Percept Mot Skills. 1998 Oct;87(2):575-84. doi: 10.2466/pms.1998.87.2.575. PMID: 9842605. PubMed Source Here are the steps:
- Warm-Up. Begin with a gentle warm-up. This can be a slow jog, some stretching, or light aerobic exercises to get your muscles ready.
- Run or Walk. Once warmed up, set a timer for 12 minutes. In these 12 minutes, try to cover as much distance as you can by running or walking at a fast pace. Ensure you have a reliable way to measure the distance covered. A standard 400m track is ideal, but using an app or wearable device that tracks distance can work too.
- Record Your Distance. At the end of the 12 minutes, record the total distance you covered.
- Calculate Your VO2 Max. Plug your result into Cooper’s VO2 Max formula:
- VO2 Max = (35.97 x miles) – 11.29
- VO2 Max = (22.351 x kilometers) – 11.288
Using Fitness Trackers
Another way is by using fitness wearables. Many modern fitness trackers and smartwatches estimate your VO2 Max based on the data they collect during your workouts.
Here is a general way to do it:
- Choose Your Activity. Select an activity from your wearable device. It can be running, walking, or cycling, depending on what your device supports.
- Workout. Start your activity, and make sure to push yourself hard during this workout. The aim is to get your heart rate up to give the device a good measure of your effort level.
- Record Your Activity. Once you’ve finished your workout, stop recording on your device. It will take some time to process your heart rate and activity data.
- Check Your VO2 Max. After your device has finished processing your data, check your fitness or health metrics. You should see an estimation of your VO2 Max among these metrics.
Age-Predicted Maximal Heart Rate (APMHR) method
There is a simple formula to estimate VO2 Max based on age. It can be done with the help of the Age-Predicted Maximal Heart Rate (APMHR) method, a simple and common method used to estimate maximum heart rate.9 Shookster D, Lindsey B, Cortes N, Martin JR. Accuracy of Commonly Used Age-Predicted Maximal Heart Rate Equations. Int J Exerc Sci. 2020 Sep 1;13(7):1242-1250. PMID: 33042384; PMCID: PMC7523886. PubMed Source
Here is the formula:
VO2 Max = 15 x (Max HR / Resting HR)
To get your maximum heart rate (Max HR), you use the formula:
Max HR = 220 – Your Age
You can measure your resting heart rate (Resting HR) by counting your heartbeats per minute when you are at rest, ideally, first thing in the morning before you get out of bed.
While this is a quick and easy method to estimate VO2 Max, it’s based on averages and may not be accurate for everyone. It can, however, provide a useful benchmark for tracking improvements over time.
Also, remember that while the at-home methods provide an estimation rather than an exact measurement, they are still useful for tracking changes in your cardiorespiratory fitness over time. With these tools in hand, you are well-equipped to track your VO2 Max and monitor your progress toward a healthier, longer life.
What Makes a ‘Good’ VO2 Max?
A ‘good’ VO2 Max can vary widely, influenced by age, sex, weight, and physical condition. However, researchers have established general VO2 Max norms to guide individuals to compare their VO2 Max with others.
There is a formula that can allow you to get a reference VO2 Max score based on your age and weight.10 Myers J, Kaminsky LA, Lima R, Christle JW, Ashley E, Arena R. A Reference Equation for Normal Standards for VO2 Max: Analysis from the Fitness Registry and the Importance of Exercise National Database (FRIEND Registry). Prog Cardiovasc Dis. 2017 Jun-Jul;60(1):21-29. doi: 10.1016/j.pcad.2017.03.002. Epub 2017 Apr 1. PMID: 28377168. PubMed Source This formula comes from a big database, called the FRIEND Registry, which is a significant initiative that analyzed extensive exercise test data from a large, diverse sample of individuals.
The formula looks as follows:
VO2 max (reference) = 79.9 – (0.39 x Your Age) – (13.7 x Gender) – (0.127 x Your Weight [lbs])
Gender: use 0 for men and 1 for women.
For adult men, a VO2 Max of about 45 to 55 ml/kg/min is typically considered good to excellent, while for women, a score of 33 to 42 ml/kg/min falls into the same category.11 Edvardsen E, Hansen BH, Holme IM, Dyrstad SM, Anderssen SA. Reference values for cardiorespiratory response and fitness on the treadmill in a 20- to 85-year-old population. Chest. 2013 Jul;144(1):241-248. doi: 10.1378/chest.12-1458. PMID: 23287878. PubMed Source Please note, these values tend to decrease with age, as our overall cardiovascular fitness generally decreases over time.
In general, the more you can improve your VO2 Max, the better your cardiovascular fitness and, therefore, your potential for longevity.
Practical Ways to Improve Your VO2 Max
Now that we have discussed the significance of VO2 Max and explored various ways to measure it, let’s pivot toward the practical side of things. How can you improve your VO2 Max, enhance your fitness, and potentially boost your longevity?
High-Intensity Interval Training (HIIT)

HIIT involves alternating periods of high-intensity exercise with periods of rest or low-intensity exercise. HIIT has been shown to effectively improve VO2 Max.12 Milanović Z, Sporiš G, Weston M. Effectiveness of High-Intensity Interval Training (HIT) and Continuous Endurance Training for VO2max Improvements: A Systematic Review and Meta-Analysis of Controlled Trials. Sports Med. 2015 Oct;45(10):1469-81. doi: 10.1007/s40279-015-0365-0. PMID: 26243014. PubMed Source
Practical Tips. After a warm-up, run or cycle as fast as you can for 30 seconds, then slow down, walk at your normal pace, and recover for a minute or two. Repeat this cycle for 20 to 30 minutes, ending with a cool-down period.
Regular Aerobic Exercise

Regular aerobic exercise, such as running, cycling, swimming, or brisk walking, can significantly improve your VO2 Max. You should aim for at least 150 minutes of moderate-intensity or 75 minutes of high-intensity aerobic exercise per week, as recommended by the American Heart Association (AHA). To achieve even better results, you can double the minimum required targets as it yields greater health benefits.13 Arem H, Moore SC, Patel A, Hartge P, Berrington de Gonzalez A, Visvanathan K, Campbell PT, Freedman M, Weiderpass E, Adami HO, Linet MS, Lee IM, Matthews CE. Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. JAMA Intern Med. 2015 Jun;175(6):959-67. doi: 10.1001/jamainternmed.2015.0533. PMID: 25844730; PMCID: PMC4451435. PubMed Source
For the most effective training of your VO2 max, it’s recommended to exercise at a high level of intensity, approximately 90 to 95 percent of your maximum heart rate.14 Helgerud J, Høydal K, Wang E, Karlsen T, Berg P, Bjerkaas M, Simonsen T, Helgesen C, Hjorth N, Bach R, Hoff J. Aerobic high-intensity intervals improve VO2max more than moderate training. Med Sci Sports Exerc. 2007 Apr;39(4):665-71. doi: 10.1249/mss.0b013e3180304570. PMID: 17414804. PubMed Source When you engage in vigorous exercise close to your heart rate’s upper limit, it fortifies your heart muscles and enhances the amount of blood your heart can pump with every beat. This, in turn, improves your VO2 max.
Practical Tips. Start with brisk walking for 30 minutes a day, five days a week. As your fitness improves, you can gradually increase your pace or include short bouts of running.
Continuous Endurance Training

This includes activities like jogging, swimming, or cycling at a steady, moderate intensity for extended periods. These exercises help improve cardiovascular fitness and, consequently, VO2 Max. It’s a potent approach to improve your VO2 Max, as it continually pushes your body to utilize oxygen more efficiently over time.
Practical Tips. Try long-distance running or cycling at a moderate pace. Begin with shorter distances and gradually increase your endurance over time. If you’re not used to long workouts, start with a comfortable baseline, like a 20-minute brisk walk or a 5-kilometer cycle ride. The idea is to select an activity and duration you can handle without strain. Over time, gradually increase the duration of your workouts. A 10% increase per week is a generally accepted guideline. Aim to work at a pace where you can talk, but not sing – this usually indicates a moderate exercise intensity which is suitable for improving endurance and VO2 Max.
Combined Interval and Continuous Training

Research suggests that alternating between high-intensity exercise and continuous endurance workouts can lead to greater improvements in VO2 Max than either method alone.15Bacon AP, Carter RE, Ogle EA, Joyner MJ. VO2max trainability and high-intensity interval training in humans: a meta-analysis. PLoS One. 2013 Sep 16;8(9):e73182. doi: 10.1371/journal.pone.0073182. PMID: 24066036; PMCID: PMC3774727. PubMed Source
One meta-study analyzed data from different other studies on this matter, and they discovered something quite remarkable: those who switched between interval training and continuous running every other day, saw the most notable improvements in their VO2 Max.
On the interval days, they did six sessions of 5-minute workouts on a stationary bike, going as hard as they could. They had 2-minute breaks between each session. On the running days, they ran for as long as they could. They started with 30 minutes in the first week, then increased to 35 minutes in the second week. For the rest of the time, they aimed to run for at least 40 minutes each day.
Keep in mind, this is a rigorous program designed for those who already have a high fitness level. But don’t let that discourage you! You can draw inspiration from this routine and adapt it to suit your current fitness level and goals.
Practical Tips. Design a workout plan that incorporates both continuous and interval training throughout the week. For instance, you could engage in three days of continuous training, such as jogging, swimming, or cycling at a moderate intensity. On two separate days, introduce high-intensity interval training into your routine. This could be in the form of sprint intervals, stair climbs, or cycling sprints.
Resistance Training

Strength training, often overlooked in the context of cardiorespiratory fitness, plays a vital role in increasing VO2 Max. It primarily does this by contributing to a higher lean mass-to-fat mass ratio in your body. More muscle and less fat can make your body more efficient at using oxygen. A few studies found an increase in VO2 max after circuit resistance training. 16 Gettman LR, Ward P, Hagan RD. A comparison of combined running and weight training with circuit weight training. Med Sci Sports Exerc. 1982;14(3):229-34. PMID: 7109892. PubMed Source 17Kaikkonen H, Yrjämä M, Siljander E, Byman P, Laukkanen R. The effect of heart rate controlled low resistance circuit weight training and endurance training on maximal aerobic power in sedentary adults. Scand J Med Sci Sports. 2000 Aug;10(4):211-5. doi: 10.1034/j.1600-0838.2000.010004211.x. PMID: 10898265. PubMed Source
This might be especially true when the individuals are just starting out or are not in great shape, to begin with.18Ozaki, H., Loenneke, J.P., Thiebaud, R.S. et al. Resistance training induced increase in VO2max in young and older subjects. Eur Rev Aging Phys Act 10, 107–116 (2013). https://doi.org/10.1007/s11556-013-0120-1 Source Strength training improves muscular strength and endurance, enhancing your performance in aerobic activities. For instance, stronger leg muscles can make you a more efficient runner, allowing you to run faster or longer with the same amount of oxygen.
Practical Tips. Include two days of strength training in your routine. This could involve weightlifting, bodyweight exercises, or resistance band workouts. A typical session could include exercises such as squats, lunges, push-ups, pull-ups, and planks. Remember to start with weights and repetitions that are comfortable for you, gradually increasing the intensity as your strength improves.
Other Factors that Matter
Balanced Diet. Your diet plays an essential role in your overall health and fitness. Consuming a diet rich in fruits, vegetables, lean protein, and whole grains can provide the energy you need for your workouts and aid in recovery. You would like to be mindful about the following components in your diet:
- Carbohydrates. The main fuel for aerobic exercises, they should be a significant part of an athlete’s diet. Whole grains, fruits, and vegetables are excellent sources of complex carbohydrates.
- Protein. Essential for muscle recovery and growth, helping you to train consistently and at a high intensity. Choose lean sources of protein such as poultry, fish, lean meats, dairy, or plant-based options like beans and lentils.
- Healthy Fats. Omega-3 and omega-6 fatty acids, found in foods like avocados, nuts, seeds, and fatty fish, are beneficial for heart health and inflammation reduction.
- Hydration. Staying properly hydrated is crucial for optimal physical performance.
- Micronutrients. Iron, which can be found in lean meats, green leafy vegetables, and fortified cereals, plays a critical role in oxygen transport. Antioxidant-rich foods, like berries, can help reduce inflammation and promote recovery.
- Beetroot Juice. Some research suggests that beetroot juice can enhance athletic performance and increase VO2 Max because of its high nitrate content, which helps improve the efficiency of the mitochondria, the powerhouse of your cells.19Domínguez R, Cuenca E, Maté-Muñoz JL, García-Fernández P, Serra-Paya N, Estevan MC, Herreros PV, Garnacho-Castaño MV. Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review. Nutrients. 2017 Jan 6;9(1):43. doi: 10.3390/nu9010043. PMID: 28067808; PMCID: PMC5295087. PubMed Source
Adequate Sleep. Sleep is critical for recovery and overall health. It ensures your body is ready for your next workout session and keeps your heart healthy. During sleep, your body produces growth hormone, which aids in repairing and rebuilding your muscles after a workout. This repair process helps your muscles become stronger and more efficient, allowing for better performance and potentially a higher VO2 Max over time. Aim for 7-9 hours of sleep per night, as recommended by the National Sleep Foundation.
Avoid Harmful Habits. Smoking, excessive alcohol consumption, and sedentary behaviors can adversely impact your cardiovascular health and VO2 Max. Thus, avoiding these habits can contribute to improving your VO2 Max.
By incorporating these practical strategies into your lifestyle, you’re not only boosting your VO2 Max, but you’re also setting the stage for a healthier, longer life. Remember, it’s never too late to start, and every small step counts!
Recap and final thoughts
VO2 Max refers to the maximum volume of oxygen your body can utilize during intense exercise. It’s a key indicator of your cardiorespiratory fitness and a powerful predictor of your overall health and longevity. Your VO2 Max can be professionally measured using an exercise stress test. At home, you can get a rough estimate using wearable fitness trackers, smartphone apps, or by using the Cooper or Rockport walking tests.
High VO2 Max levels are associated with a lower risk of chronic diseases, better heart health, and greater longevity. VO2 Max naturally declines with age, but regular training can significantly slow this rate of decline. A ‘good’ VO2 Max varies based on factors like age, sex, and fitness level. There are established reference norms to help you understand where you stand.
You can enhance your VO2 Max through regular aerobic exercise, high-intensity interval training (HIIT), endurance and strength training, and combining interval and continuous aerobic training. Nutrition and good sleep hygiene also play crucial roles in this process.
References
- 1Shephard RJ, Balady GJ. Exercise as cardiovascular therapy. Circulation. 1999 Feb 23;99(7):963-72. doi: 10.1161/01.cir.99.7.963. PMID: 10027821. Source
- 2Hawkins MN, Raven PB, Snell PG, Stray-Gundersen J, Levine BD. Maximal oxygen uptake as a parametric measure of cardiorespiratory capacity. Med Sci Sports Exerc. 2007 Jan;39(1):103-7. doi: 10.1249/01.mss.0000241641.75101.64. Erratum in: Med Sci Sports Exerc. 2007 Mar;39(3):574. PMID: 17218891. PubMed Source
- 3Khan H, Kunutsor S, Rauramaa R, Savonen K, Kalogeropoulos AP, Georgiopoulou VV, Butler J, Laukkanen JA. Cardiorespiratory fitness and risk of heart failure: a population-based follow-up study. Eur J Heart Fail. 2014 Feb;16(2):180-8. doi: 10.1111/ejhf.37. Epub 2013 Dec 14. PMID: 24464981. PubMed Source
- 4Strasser B, Burtscher M. Survival of the fittest: VO2max, a key predictor of longevity? Front Biosci (Landmark Ed). 2018 Mar 1;23(8):1505-1516. doi: 10.2741/4657. PMID: 29293447. PubMed Source
- 5Fleg JL, Morrell CH, Bos AG, Brant LJ, Talbot LA, Wright JG, Lakatta EG. Accelerated longitudinal decline of aerobic capacity in healthy older adults. Circulation. 2005 Aug 2;112(5):674-82. doi: 10.1161/CIRCULATIONAHA.105.545459. Epub 2005 Jul 25. PMID: 16043637. PubMed Source
- 6Hawkins SA, Wiswell RA, Marcell TJ. Exercise and the master athlete–a model of successful aging? J Gerontol A Biol Sci Med Sci. 2003 Nov;58(11):1009-11. doi: 10.1093/gerona/58.11.m1009. PMID: 14630882. PubMed Source
- 7Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, Sugawara A, Totsuka K, Shimano H, Ohashi Y, Yamada N, Sone H. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA. 2009 May 20;301(19):2024-35. doi: 10.1001/jama.2009.681. PMID: 19454641. PubMed Source
- 8McNaughton L, Hall P, Cooley D. Validation of several methods of estimating maximal oxygen uptake in young men. Percept Mot Skills. 1998 Oct;87(2):575-84. doi: 10.2466/pms.1998.87.2.575. PMID: 9842605. PubMed Source
- 9Shookster D, Lindsey B, Cortes N, Martin JR. Accuracy of Commonly Used Age-Predicted Maximal Heart Rate Equations. Int J Exerc Sci. 2020 Sep 1;13(7):1242-1250. PMID: 33042384; PMCID: PMC7523886. PubMed Source
- 10Myers J, Kaminsky LA, Lima R, Christle JW, Ashley E, Arena R. A Reference Equation for Normal Standards for VO2 Max: Analysis from the Fitness Registry and the Importance of Exercise National Database (FRIEND Registry). Prog Cardiovasc Dis. 2017 Jun-Jul;60(1):21-29. doi: 10.1016/j.pcad.2017.03.002. Epub 2017 Apr 1. PMID: 28377168. PubMed Source
- 11Edvardsen E, Hansen BH, Holme IM, Dyrstad SM, Anderssen SA. Reference values for cardiorespiratory response and fitness on the treadmill in a 20- to 85-year-old population. Chest. 2013 Jul;144(1):241-248. doi: 10.1378/chest.12-1458. PMID: 23287878. PubMed Source
- 12Milanović Z, Sporiš G, Weston M. Effectiveness of High-Intensity Interval Training (HIT) and Continuous Endurance Training for VO2max Improvements: A Systematic Review and Meta-Analysis of Controlled Trials. Sports Med. 2015 Oct;45(10):1469-81. doi: 10.1007/s40279-015-0365-0. PMID: 26243014. PubMed Source
- 13Arem H, Moore SC, Patel A, Hartge P, Berrington de Gonzalez A, Visvanathan K, Campbell PT, Freedman M, Weiderpass E, Adami HO, Linet MS, Lee IM, Matthews CE. Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. JAMA Intern Med. 2015 Jun;175(6):959-67. doi: 10.1001/jamainternmed.2015.0533. PMID: 25844730; PMCID: PMC4451435. PubMed Source
- 14Helgerud J, Høydal K, Wang E, Karlsen T, Berg P, Bjerkaas M, Simonsen T, Helgesen C, Hjorth N, Bach R, Hoff J. Aerobic high-intensity intervals improve VO2max more than moderate training. Med Sci Sports Exerc. 2007 Apr;39(4):665-71. doi: 10.1249/mss.0b013e3180304570. PMID: 17414804. PubMed Source
- 15Bacon AP, Carter RE, Ogle EA, Joyner MJ. VO2max trainability and high-intensity interval training in humans: a meta-analysis. PLoS One. 2013 Sep 16;8(9):e73182. doi: 10.1371/journal.pone.0073182. PMID: 24066036; PMCID: PMC3774727. PubMed Source
- 16Gettman LR, Ward P, Hagan RD. A comparison of combined running and weight training with circuit weight training. Med Sci Sports Exerc. 1982;14(3):229-34. PMID: 7109892. PubMed Source
- 17Kaikkonen H, Yrjämä M, Siljander E, Byman P, Laukkanen R. The effect of heart rate controlled low resistance circuit weight training and endurance training on maximal aerobic power in sedentary adults. Scand J Med Sci Sports. 2000 Aug;10(4):211-5. doi: 10.1034/j.1600-0838.2000.010004211.x. PMID: 10898265. PubMed Source
- 18Ozaki, H., Loenneke, J.P., Thiebaud, R.S. et al. Resistance training induced increase in VO2max in young and older subjects. Eur Rev Aging Phys Act 10, 107–116 (2013). https://doi.org/10.1007/s11556-013-0120-1 Source
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